Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach

AUTOR(ES)

Elemento, Olivier

FONTE

BioMed Central

RESUMO

The authors describe a powerful approach for discovering globally conserved regulatory elements between two genomes that does not require alignments. Its application to pairs of yeasts, worm, flies and mammals, yields a large number of known and novel putative regulatory elements, many of which show surprising conservation across large phylogenetic distances.

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