Fatal Quinidine-Induced Thrombocytopenia following Open-Heart Surgery
AUTOR(ES)
Brenner, William I.
RESUMO
Three patients developed quinidine-induced thrombocytopenia within 3 months of our initiating quinidine therapy after open-heart surgery. One patient recovered from thrombocytopenic purpura after quinidine was discontinued. The 2 other patients presented with thrombocytopenic purpura and gingival bleeding over several days. Both patients developed headaches and succumbed to intracerebral hemorrhage in spite of the immediate cessation of quinidine therapy on admission and treatment with corticosteroids and platelet transfusions.
