Features to validate cerebral toxoplasmosis

AUTOR(ES)

Correia, Carolina da Cunha, Melo, Heloisa Ramos Lacerda, Costa, Vlaudia Maria Assis, Brainer, Alessandra Mertens

FONTE

Rev. Soc. Bras. Med. Trop.

DATA DE PUBLICAÇÃO

2013-06

RESUMO

Introduction Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fluid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results In 8.5%, focal neurological deficits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions Patients with NT may present without focal neurological deficit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fluid improve the sensitivity of PCR to T gondii.

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