Fermentation Studies with Streptomyces griseus: II. Synthetic Media for the Production of Streptomycin
AUTOR(ES)
Shirato, Shiroh
RESUMO
Synthetic media for streptomycin fermentation were studied to determine which media gave highest yields of streptomycin. The effect of salts on streptomycin production by Streptomyces griseus was examined, and a suitable combination of salts was established in a glucose-casein medium. This medium yielded 3,000 μg/ml of the antibiotic with an inoculum of 1.6%. Substitution of amino acids for casein was examined. Of 17 amino acids tested, best results were obtaind with sodium aspartate. Substitution of ammonium salts was tried, and an excellent streptomycin yield was obtained with a medium containing ammonium citrate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1058400Documentos Relacionados
- Fermentation Studies with Streptomyces griseus: I. Carbohydrate Sources for the Production of Protease and Streptomycin
- Observations on Streptomyces griseus: II. Nitrogen Sources for Growth and Streptomycin Production 1
- Antibiotic Production of Hyphal Fractions of Streptomyces griseus: II. Streptomycin Production of Different Fractions Obtained by Density Gradient Centrifugation
- Cycloheximide Production by Streptomyces griseus: Alleviation of End-Product Inhibition by Dialysis-Extraction Fermentation
- STUDIES ON THE BIOCHEMISTRY OF THE STREPTOMYCES I. Streptomyces griseus: Terminal Oxidative Metabolism in