Flow injection determination of metronidazole through spectrophotometric measurement of the nitrite ion produced upon alkaline hydrolysis

AUTOR(ES)

Simões, Simone S., Medeiros, Everaldo P., Gaião, Edvaldo N., Lyra, Wellington S., Moreira, Pablo N. T., Araújo, Mario C. U., Silva, Edvan C., Nascimento, Valberes B.

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2006-06

RESUMO

Um novo método para determinação de metronidazol, baseado no monitoramento espectrométrico do sal de diazônio produzido in-line pelos íons nitrito, liberados numa hidrólise alcalina, foi desenvolvido e aplicado com sucesso a comprimidos (r = 0,9993, 2,0-20,0 mg L-1, LD = 0,7 mg L-1), sem interferência de ingredientes comumente presentes.

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