From cell death to embryo arrest: Mathematical models of human preimplantation embryo development
AUTOR(ES)
Hardy, K.
FONTE
The National Academy of Sciences
RESUMO
Human preimplantation embryos exhibit high levels of apoptotic cells and high rates of developmental arrest during the first week in vitro. The relation between the two is unclear and difficult to determine by conventional experimental approaches, partly because of limited numbers of embryos. We apply a mixture of experiment and mathematical modeling to show that observed levels of cell death can be reconciled with the high levels of embryo arrest seen in the human only if the developmental competence of embryos is already established at the zygote stage, and environmental factors merely modulate this. This suggests that research on improving in vitro fertilization success rates should move from its current concentration on optimizing culture media to focus more on the generation of a healthy zygote and on understanding the mechanisms that cause chromosomal and other abnormalities during early cleavage stages.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=29312Documentos Relacionados
- HLA-G expression during preimplantation human embryo development.
- The Unfolded Protein Response Contributes to Preimplantation Mouse Embryo Death in the DDK Syndrome1
- Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.
- Antisense c-myc effects on preimplantation mouse embryo development.
- DNA damage and p53-mediated cell cycle arrest: A reevaluation