From fruitflies to mammals: mechanisms of signalling via the Sonic hedgehog pathway in lung development
AUTOR(ES)
van Tuyl, Minke
FONTE
BioMed Central
RESUMO
The hedgehog signalling pathway has been implicated in many different processes in fly and vertebrate development. It is now known that the hedgehog cascade is crucial for the patterning of the early respiratory system. Hedgehog signalling in the lung involves Gli transcription proteins, but their potential downstream target genes have yet to be identified. Bmp4 and Fgf10 have been shown to regulate lung branching morphogenesis but seem not to be targets of hedgehog signalling.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=59539Documentos Relacionados
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