Functional Profile of the Isolated Uremic Nephron: EVIDENCE OF PROXIMAL TUBULAR “MEMORY” IN EXPERIMENTAL RENAL DISEASE
AUTOR(ES)
Trizna, Walter
RESUMO
In experimental models of glomerular and nonglomerular renal disease, single nephron filtration rate and proximal tubular reabsorption of fluid decrease or increase in parallel in the same nephron. To assess whether intrinsic adaptations in proximal tubular function, i.e., changes that are independent of the peritubular or humoral milieu, contribute to this phenomenon, segments of rabbit late superficial proximal convoluted tubules (PCT) were studied by in vitro perfusion. PCT were obtained from normal kidneys, from remnant kidneys, and from kidneys embolized with microspheres. Single nephron filtration rates are increased in the remnant and decreased in the embolized kidneys. Whereas the embolized-kidney rabbits were nonazotemic (the contralateral kidney was left in situ), the remnant-kidney animals were uremic. In order to study a nonazotemic model of increased single nephron filtration rate, PCT were also obtained from uninephrectomized rabbits.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=370858Documentos Relacionados
- Functional profile of the isolated uremic nephron: potassium adaptation in the rabbit cortical collecting tubule.
- Functional Profile of the Isolated Uremic Nephron: ROLE OF COMPENSATORY HYPERTROPHY IN THE CONTROL OF FLUID REABSORPTION BY THE PROXIMAL STRAIGHT TUBULE
- Functional Profile of the Isolated Uremic Nephron: IMPAIRED WATER PERMEABILITY AND ADENYLATE CYCLASE RESPONSIVENESS OF THE CORTICAL COLLECTING TUBULE TO VASOPRESSIN
- The effect of bradykinin on proximal tubular sodium reabsorption in the dog: evidence for functional nephron heterogeneity
- Fluid Secretion in Isolated Proximal Straight Renal Tubules EFFECT OF HUMAN UREMIC SERUM