Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
AUTOR(ES)
Mendez-Otero, R., Santiago, M.F.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2003-08
RESUMO
Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our findings that demonstrate the functional role of this molecule in neuronal motility.
Documentos Relacionados
- Versican V1 Isoform Induces Neuronal Differentiation and Promotes Neurite Outgrowth
- Function of ganglioside 9-O-acetyl GD3 in neuronal migration
- A Role for the Cytoskeleton-associated Protein Palladin in Neurite Outgrowth
- Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth
- Protein Kinase MARK/PAR-1 Is Required for Neurite Outgrowth and Establishment of Neuronal Polarity