Further evidence for preaxial hallucal polydactyly as a marker of diabetic embryopathy.

AUTOR(ES)

Slee, J

RESUMO

Maternal diabetes has an established aetiological link with developmental abnormalities, and the prevalence of major congenital malformations in the offspring of affected women is approximately 4-8%, compared to the general population risk of about 3%. Hallucal polydactyly, particularly with an unusual proximal placement of the extra digit, has been reported as a distinctive anomaly in diabetic embryopathy. We report on a child of a diabetic mother with this unusual form of hallucal polydactyly, together with other skeletal anomalies, confirming that this malformation is a useful clinical marker for the diagnosis of diabetic embryopathy.

Documentos Relacionados

• Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly
• Another case of microcephaly, facial clefting, and preaxial polydactyly.
• Unknown syndrome: microcephaly, facial clefting, and preaxial polydactyly.
• Lethal short rib-polydactyly syndromes: further evidence for their overlapping in a continuous spectrum.
• Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.