Gap junctional conductance: comparison of sensitivities to H and Ca ions.
AUTOR(ES)
Spray, D C
RESUMO
One cytoplasmic aspect of the junctional membrane between coupled pairs of Fundulus blastomeres was perfused with solutions of known H and Ca ion concentrations. Conductance of junctional membrane was decreased by either ion. The sensitivity to H ions was about 10,000 times greater than that to Ca ions. The results suggest that junctional conductance can be modulated by changes in H ion concentration near physiological pH, but that unphysiologically high concentrations of Ca ion, such as would be reached only on cell death, are required for comparable changes in junctional conductance.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345759Documentos Relacionados
- Sensitivity of gap junctional conductance to H ions in amphibian embryonic cells is independent of voltage sensitivity.
- Ca2+/calmodulin-dependent kinase II mediates simultaneous enhancement of gap-junctional conductance and glutamatergic transmission
- Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.
- Reduction of gap junctional conductance by microinjection of antibodies against the 27-kDa liver gap junction polypeptide.
- cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide.