Gene expression of a gene family in maize based on noncollinear haplotypes
AUTOR(ES)
Song, Rentao
FONTE
National Academy of Sciences
RESUMO
Genomic regions of nearly every species diverged into different haplotypes, mostly based on point mutations, small deletions, and insertions that do not affect the collinearity of genes within a species. However, the same genomic interval containing the z1C gene cluster of two inbred lines of Zea mays significantly lost their gene collinearity and also differed in the regulation of each remaining gene set. Furthermore, when inbreds were reciprocally crossed, hybrids exhibited an unexpected shift of expression patterns so that “overdominance” instead of “dominance complementation” of allelic and nonallelic gene expression occurred. The same interval also differed in length (360 vs. 263 kb). Segmental rearrangements led to sequence changes, which were further enhanced by the insertion of different transposable elements. Changes in gene order affected not only z1C genes but also three unrelated genes. However, the orthologous interval between two subspecies of rice (not rice cultivars) was conserved in length and gene order, whereas changes between two maize inbreds were as drastic as changes between maize and sorghum. Given that chromosomes could conceivably consist of intervals of haplotypes that are highly diverged, one could envision endless breeding opportunities because of their linear arrangement along a chromosome and their expression potential in hybrid combinations (“binary” systems). The implication of such a hypothesis for heterosis is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=166437Documentos Relacionados
- Dosage Effects on Gene Expression in a Maize Ploidy Series
- Differential expression and sequence analysis of the maize glyceraldehyde-3-phosphate dehydrogenase gene family.
- The reduced expression of endogenous duplications (REED) in the maize R gene family is mediated by DNA methylation.
- Transmission/Disequilibrium Test Meets Measured Haplotype Analysis: Family-Based Association Analysis Guided by Evolution of Haplotypes
- Heat Inducible Expression of a Chimeric Maize hsp70CAT Gene in Maize Protoplasts 1