Gene expression profiles of primary breast tumors maintained in distant metastases
AUTOR(ES)
Weigelt, Britta
FONTE
National Academy of Sciences
RESUMO
It has been debated for decades how cancer cells acquire metastatic capability. It is unclear whether metastases are derived from distinct subpopulations of tumor cells within the primary site with higher metastatic potential, or whether they originate from a random fraction of tumor cells. Here we show, by gene expression profiling, that human primary breast tumors are strikingly similar to the distant metastases of the same patient. Unsupervised hierarchical clustering, multidimensional scaling, and permutation testing, as well as the comparison of significantly expressed genes within a pair, reveal their genetic similarity. Our findings suggest that metastatic capability in breast cancer is an inherent feature and is not based on clonal selection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=307665Documentos Relacionados
- E-cadherin expression in primary carcinomas of the breast and its distant metastases
- Gene expression profiles of human breast cancer progression
- Predicting the clinical status of human breast cancer by using gene expression profiles
- Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice
- Distant metastases from a malignant glioma: unusual complications associated with treatment of a glioblastoma: distant metastases and focal white matter degeneration.