Genes controlling segmental specification in the Drosophila thorax.
AUTOR(ES)
Struhl, G
RESUMO
The roles of three homeotic genes, Ubx+, Scr+, and Antp+, in the Drosophila thorax have been studied by determining the cellular phenotypes of mutations resulting in loss of gene function. The principal results are: (i) The Scr+ and Ubx+ genes are required in the prothorax and metathorax, respectively; in the absence of these genes, both segments develop like the mesothorax. (ii) The Antp+ gene is required in all three thoracic segments: in its absence, parts of the mesothorax are transformed into corresponding parts of the antenna, and similar transformations to antenna are found in the prothorax and metathorax if the Scr+ and Ubx+ genes also are absent. (iii) Loss of the Ubx+ gene early in embryogenesis, but not later, leads to the inappropriate activity of the Scr+ gene in the meso- and metathorax. Results i and ii argue strongly that segmental determination is specified in a combinatorial fashion in the head and thorax by the selective activities of the Scr+, Ubx+, Antp+, and putative head-determining genes. Result iii suggests that a product of the Ubx+ gene also plays an early, regulatory role in ensuring the correct spatial expression of the Scr+ gene during subsequent development.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347343Documentos Relacionados
- Radiographic assessment of pleuropulmonary disease in asbestos workers: posteroanterior, four view films, and computed tomograms of the thorax.
- The Thorax. Part A: Physiology; Part B: Applied Physiology; Part C: Disease (Lung Biology in Health and Disease Series, No 85)
- Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.
- Polymorphism in Natural Populations for Genes Controlling Radioresistance in Drosophila
- Segmental Aneuploidy as a Probe for Structural Genes in Drosophila: Mitochondrial Membrane Enzymes