Genetic and epigenetic networks controlling T helper 1 cell differentiation
AUTOR(ES)
Placek, Katarzyna
FONTE
Blackwell Science Inc
RESUMO
Significant progress has been made during the past years in our understanding of the mechanisms that control the differentiation of naïve CD4+ T cells into effector T-cell subsets with distinct functional properties. Previous work allowed the identification of key molecules involved in regulating this highly complex process, such as cytokines and their receptors, signal transducers and transcription factors. More recently, the emphasis of research in this field has been to elucidate how the multiplicity of signals is integrated to shape a T helper subset-specific gene-expression program controlling differentiation and effector functions. In this review we will highlight advances that have been made in unravelling the genetic and epigenetic networks controlling differentiation of naïve CD4+ T cells into interferon-γ(IFN-γ)-secreting T helper type 1 (Th1) cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2691780Documentos Relacionados
- Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.
- Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
- Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
- Cell fate decision: T-helper 1 and 2 subsets in immune responses
- Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation