Genetic Control of Alkaline Phosphatase Synthesis in Neurospora: The Use of Partial Diploids in Dominance Studies
AUTOR(ES)
Metzenberg, Robert L.
RESUMO
In wild-type Neurospora, alkaline phosphatase is made under conditions of phosphate limitation, but not conditions of phosphate sufficiency. Mutants at two unlinked loci, nuc-1 and nuc-2, do not make alkaline phosphatase under any conditions, while mutants at two quite closely linked loci, pcon and preg, make alkaline phosphatase even under conditions of phosphate sufficiency. pcon is extremely closely linked to nuc-2. nuc-2 and pregc (constitutive) mutants are recessive to their wild-type alleles in partial diploids as well as in heterokaryons, while pconc mutants are dominant or co-dominant. nuc-1 is epistatic to both pconc and pregc mutants. The implications of these findings for theories of metabolic control in eukaryotes are briefly discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213116Documentos Relacionados
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