GENETIC CONTROL OF IMMUNOLOGICAL RESPONSIVENESS IN GUINEA PIGS TO 2,4-DINITROPHENYL CONJUGATES OF POLY-L-ARGININE, PROTAMINE, AND POLY-L-ORNITHINE

AUTOR(ES)

Green, Ira

RESUMO

The ability of guinea pigs to respond immunologically to dinitrophenyl (DNP)-poly-L-arginine, DNP-protamine, DNP polyornithine, and to unsubstituted poly-L-arginine and protamine is linked to the presence of the poly-L-lysine gene. This gene has previously been demonstrated to control the immune response of guinea pigs to poly-L-lysine, to a copolymer of L-glutamic acid and L-lysine and to haptenic derivatives of these materials.

Documentos Relacionados

• Synthesis and antibody-mediated detection of oligonucleotides containing multiple 2,4-dinitrophenyl reporter groups.
• Inhibition of murine leukemia virus with poly-2'-O-(2,4-dinitrophenyl)poly[A]
• Efficient DNA transfection of quiescent mammalian cells using poly-L-ornithine.
• Introduction of antigenic determining 2,4-dinitrophenyl residues into 4-thiouridine, N3-(3-L-amino-3-carboxypropyl) uridine and tRNA-Phe from E. coli.
• Immunological responsiveness of guinea pigs to antibiotics diffusing from bone cement.