Genetic instability in patients with Hodgkin's disease undergoing chemotherapy.
AUTOR(ES)
Abdallah, J M
RESUMO
We have studied the effect of chemotherapy on the level of a particular kind of genetic instability in patients with Hodgkin's disease. The particular type of genetic instability assayed is exemplified by trans-rearrangements between two (rather than within one) T cell antigen receptor. 16 patients were studied during their course of treatment. Presentation samples were available for 13 of these patients; 9 of them showed an increase in the level of trans-rearrangements during their exposure to chemotherapeutic agents (P < 0.043). All patients for whom posttherapy samples were available (10 out of 16) showed a return to baseline levels of trans-rearrangements 1-5 mo after completion of therapy (P < 0.03). Thus, this assay appears to be a marker for the "destabilizing" effects of certain chemotherapeutic agents.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185983Documentos Relacionados
- Reticuloendothelial System Phagocytic Function in Patients with Hodgkin's Disease*
- Lung carcinoma after radiotherapy and chemotherapy for Hodgkin's disease.
- Primary pulmonary histiocytosis X in two patients with Hodgkin's disease
- B Lymphocytes in Untreated Patients with Malignant Lymphoma and Hodgkin's Disease
- Torulosis Associated with Hodgkin's Disease