GENETIC MODIFIERS OF STREPTOMYCIN RESISTANCE IN PNEUMOCOCCUS
AUTOR(ES)
Bryan, Betty E.
RESUMO
Bryan, Betty E. (University of Rochester, Rochester, N. Y.). Genetic modifiers of streptomycin resistance in pneumococcus. J. Bacteriol. 82:461–470. 1961.—Streptomycin-resistant mutants arising spontaneously in pneumococcus vary widely with respect to the maximal concentrations of streptomycin which they resist. A small random sample of these mutations tested for linkage are allelic or closely linked. One single-step mutant resisting a relatively low level of streptomycin undergoes the following changes: (i) replacement (by a secondary mutation) of the original mutation by an allele conferring a high level of resistance; (ii) reversion to complete sensitivity by back mutation at the originally mutated site; (iii) enhancement by an unlinked modifier gene which confers no resistance by itself but raises the level of resistance of the mutant strain approximately 10-fold. This modifier may have some specificity in its action on the different mutations occurring at a gene locus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=279193Documentos Relacionados
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