Genotoxic effect of alkaloids

AUTOR(ES)

Henriques, Joao Antonio Pegas

DATA DE PUBLICAÇÃO

2010

RESUMO

Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showed genotoxícity in the presence of a metabolic activation mixture. Voacristine isolated from the leaves of Ervatamia coronaria shows in vivo cytostatic and mu tagenic effects in Saccharomyces cerevisiae hapioids cells. The Rauwolfia alkaloid (reserpine) was not able to induce reverse mutation and recombinational mitotic events (crossing-over and gene conversion) in yeast diploid strain XS2316.

ASSUNTO(S)

alkaloíds alcaloides : genotoxicidade : saccharomyces cerevisiae sos-chromotest alcalóides sos chromoteste saccharomyces cerevisiae mutation saccharomyces cerevisiae genotoxicidade recombination

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