Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids
AUTOR(ES)
Guimarães, Larissa O., Andrade, Fabiana A. de, Bono, Gleyse F., Setoguchi, Thaís E., Brandão, Mariana B., Chautard-Freire-Maia, Eleidi A., Santos, Izabella C.R. dos, Picheth, Geraldo, Faria, Ana Cristina R. de A., Réa, Rosângela R., Souza, Ricardo L.R., Furtado-Alle, Lupe
FONTE
Genet. Mol. Biol.
DATA DE PUBLICAÇÃO
2014
RESUMO
Many conditions interfere with butyrylcholinesterase (BChE) activity, e.g., pregnancy or presence of the BCHE gene variant -116A can decrease activity whereas obesity and types I and II diabetes mellitus can increase activity. In this study, we examined BChE activity, -116A and 1615A BCHE gene variants, and anthropometric and biochemical variables associated with diabetes in patients with gestational diabetes mellitus (GDM) and in healthy pregnant women. BChE activity was measured spectrophotometrically using propionylthiocholine as substrate and genotyping of the -116 and 1615 sites of the BCHE gene was done with a TaqMan SNP genotyping assay. Three groups were studied: 150 patients with GDM, 295 healthy pregnant women and 156 non-pregnant healthy women. Mean BChE activity was significantly lower in healthy pregnant women than in women from the general population and was further reduced in GDM patients. BChE activity was significantly reduced in carriers of -116A in GDM patients and healthy pregnant women. Although GDM patients had a significantly higher mean body mass index (BMI) and triglycerides than healthy pregnant women, they had lower mean BChE activity, suggesting that the lowering effect of GDM on BChE activity was stronger than the characteristic enhancing effect of increased BMI and triglycerides.
Documentos Relacionados
- Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine
- The butyrylcholinesterase gene (BCHE) at 3q26.2 shows two RFLPs
- Changes in Sweet Taste Across Pregnancy in Mild Gestational Diabetes Mellitus: Relationship to Endocrine Factors
- The relationship of flavonoid intake during pregnancy with excess body weight and gestational diabetes mellitus
- Relationship between minimally and ultra-processed food intake during pregnancy with obesity and gestational diabetes mellitus