Global Stage-Specific Gene Regulation during the Developmental Cycle of Chlamydia trachomatis
AUTOR(ES)
Nicholson, Tracy L.
FONTE
American Society for Microbiology
RESUMO
Distinct morphological changes associated with the complex development cycle of the obligate intracellular bacterial pathogen Chlamydia trachomatis have been historically well characterized by microscopy. A number of temporally regulated genes have been characterized previously, suggesting that the chlamydial developmental cycle is regulated at the transcriptional level. This hypothesis was tested by microarray analysis in which the entire C. trachomatis genome was analyzed, providing a comprehensive assessment of global gene regulation throughout the chlamydial developmental cycle. Seven temporally cohesive gene clusters were identified, with 22% (189 genes) of the genome differentially expressed during the developmental cycle. The correlation of these gene clusters with hallmark morphological events of the chlamydial developmental cycle suggests three global stage-specific networks of gene regulation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=154084Documentos Relacionados
- Developmental stage-specific regulation of atrial natriuretic factor gene transcription in cardiac cells.
- Developmental stage-specific and nitrate-independent regulation of nitrate reductase gene expression in rapeseed.
- A novel developmental stage-specific lectin of the basidiomycete Pleurotus cornucopiae.
- Stage-specific patterns of collagen gene expression during development of Caenorhabditis elegans.
- A developmental stage-specific histone H1 homolog of Coxiella burnetii.