Glutathione S-transferase in bone marrow metastases of disseminated neuroblastoma.
AUTOR(ES)
Hall, A G
RESUMO
Antisera to each of the three main cytosolic forms of glutathione S-transferase (GST; alpha, mu, and pi) has been used to characterise GST expression by metastatic neuroblastoma in bone marrow trephine biopsies taken from 15 patients at presentation and from five of this group at relapse. There was no correlation between expression of extra-nuclear alpha or mu GST and outcome, and no consistent pattern at relapse. Seven of eight expressing nuclear pi GST at presentation died of resistant disease. Three of five cases with no detectable nuclear pi class GST remain alive and disease free. The results provide no encouragement for further investigation of alpha or mu GST in this disease but larger studies of uniformly treated patients may show whether nuclear pi GST expression at presentation indicates likely relapse.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=502030Documentos Relacionados
- Immunocytochemical examination of bone marrow in disseminated neuroblastoma.
- Drosophila glutathione S-transferase 1-1 shares a region of sequence homology with the maize glutathione S-transferase III.
- Glutathione S-Transferase Isoenzymes from Streptomyces griseus
- A novel type of glutathione S-transferase in Onchocerca volvulus.
- Two RFLPs at the glutathione S-transferase 3 gene