Glycoprotein I of Varicella-Zoster Virus Is Required for Viral Replication in Skin and T Cells
AUTOR(ES)
Moffat, Jennifer
FONTE
American Society for Microbiology
RESUMO
Varicella-zoster virus (VZV) glycoprotein I (gI) is dispensable in cell culture; the SCIDhu model of VZV pathogenesis was used to determine whether gI is necessary in vivo. The parental and repaired viruses grew in human skin and thymus/liver implants, but the gI deletion mutant was not infectious. Thus, gI is essential for VZV infectivity in skin and T cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=155157Documentos Relacionados
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