Group A Streptococcal Polysaccharide Antigens
AUTOR(ES)
Matsuno, Takashi
RESUMO
Cold trichloroacetic acid extracts of group A, type 3 streptococci were fractionated on Sephadex G50 and ECTEOLA cellulose columns. A glucose-N-acetylglucosamine polymer was isolated and shown by chemical, electrophoretic, and antigenic analysis to be distinct from the group A polysaccharide. The antigenic specificity was due to the glucosamine. A glycerol-phosphate-alanine-glucosamine teichoic acid polymer was isolated. The antigenic specificity was due to N-acetylglucosamine and d-alanine methyl ester, with the former possessing principal responsibility. The glucosamine and ester-linked alanine appear to be labile to the method of extraction and fractionation. Group A streptococcal whole cell antiserum, after adsorption with cells of a heterologous serological group and group A polysaccharide antigen, contained antibodies against both polymers.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=416162Documentos Relacionados
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