Growth control of influenza A virus by M1 protein: analysis of transfectant viruses carrying the chimeric M gene.
AUTOR(ES)
Yasuda, J
RESUMO
Analysis of fast-growing reassortants (AWM viruses) of influenza A virus produced by mixed infection with a fast-growing WSN strain and a slowly growing Aichi strain indicated that the M gene plays a role in the regulation of virus growth rate at an early step of infection (J. Yasuda, T. Toyoda, M. Nakayama, and A. Ishihama, Arch. Virol. 133:283-294, 1993). To determine which of the two M gene products, M1 or M2, is responsible for the growth rate control, one recombinant WSN virus (CWA) clone possessing a chimeric M gene (WSN M1-Aichi M2) was generated by using an improved reverse genetics and transfection system. The recombinant CWA virus retained the phenotype of both large plaque formation and early onset of virus growth. This indicates that the WSN M1 protein is responsible for rapid virus growth.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=237279Documentos Relacionados
- Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein.
- Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins.
- Influenza virus NS1 protein stimulates translation of the M1 protein.
- Mechanism of attenuation of a chimeric influenza A/B transfectant virus.
- Influenza Virus Assembly: Effect of Influenza Virus Glycoproteins on the Membrane Association of M1 Protein
