Habituation in the single cell: diminished secretion of norepinephrine with repetitive depolarization of PC12 cells.
AUTOR(ES)
McFadden, P N
RESUMO
Neuronally differentiated PC12 cells secrete decreasing amounts of [3H]norepinephrine when repetitively stimulated by depolarizing concentrations of potassium ion. The decreasing response shows attributes that have been classically ascribed to response habituation, a behavior commonly observed in nervous systems but found here in a homogeneous cell type. Alteration of the habituation pattern was caused by activators of the protein kinase C pathway and of voltage-gated calcium channels.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=53619Documentos Relacionados
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