Halogenation of tubercidin by N-halosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells.
AUTOR(ES)
Bergstrom, D E
RESUMO
Tubercidin may be directly brominated by reaction with N-bromosuccinimide in DMF to give 5-bromotubercidin, a reversible inhibitor of RNA synthesis. When buffered with potassium acetate the major product is 6-bromotubercidin. 5,6-Dibromotubercidin is formed in minor amounts under both conditions. N-Chlorosuccinimide and tubercidin give 5-chlorotubercidin and 5,6-dichlorotubercidin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=328083Documentos Relacionados
- Ribosome Formation is Blocked by Camptothecin, a Reversible Inhibitor of RNA Synthesis
- Biological consequences of incorporation of 5-fluorocytidine in the RNA of 5-fluorouracil-treated eukaryotic cells.
- Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis.
- Sensitivity to UV radiation of small nuclear RNA synthesis in mammalian cells.
- Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes.