Heart Transplantation for Chagas Cardiomyopathy
AUTOR(ES)
Moreira, Maria da Consolação; Castilho, Fabio Morato; Braulio, Renato; Andrade, Guilherme Ferraz Messina de Pádua; Melo, José Renan da Cunha
FONTE
Int. J. Cardiovasc. Sci.
DATA DE PUBLICAÇÃO
2020-12
RESUMO
Abstract Heart transplantation (HT) is an established treatment for patients with advanced heart failure (HF). Chagas disease (CD), caused by the Trypanosoma cruzi (T.cruzi) is an important cause of HF in Latin America. Considering CD is a chronic infectious disease, the use of immunosuppressive therapy after HT can reactivate T. cruzi infection and compromise outcomes. Early diagnosis and treatment of this complication is extremely important, which requires knowledge, experience, and a high degree of suspicion by transplant physicians. Furthermore, with the international immigration of people, CD is no longer exclusive to Latin America, since a large number of immigrants with T. cruzi infection are living in non-endemic countries. This phenomenon represents not only a new global epidemiological problem, but also a challenge for transplant teams. This review aims to discuss the peculiarities of HT in the context of CD, with a focus on reactivation of the infection, clinical manifestations, etiological treatment of T. cruzi and differential diagnosis with allograft rejection, among HT recipients.
Documentos Relacionados
- Nontransplant Cardiac Surgery: as a Bridge to Heart Transplantation in Pediatric Dilated Cardiomyopathy
- ERRATUM: Chagas Disease Cardiomyopathy
- Histoplasmosis as a late infectious complication following heart transplantation in a patient with Chagas' disease
- Case 4/2019 - 26-Year-Old Man with Congenital Chagas Disease and Heart Transplantation
- Heart transplantation for Churg-Strauss syndrome.