Hepatic metabolism of free fatty acids in normal and diabetic dogs

AUTOR(ES)

Basso, Laurence V.

RESUMO

Fasted dogs prepared with catheters in the femoral artery, portal vein, and hepatic vein and infused intravenously with palmitate-1-14C were used to estimate uptake of free fatty acids in liver and their conversion to major metabolic products secreted into hepatic venous blood. Animals were studied under ordinary conditions and when fat mobilization was increased abruptly by infusing norepinephrine or for a prolonged period by withdrawing insulin from depancreatized dogs. 80% of hepatic blood flow was assumed to be derived from the portal vein.

Documentos Relacionados

• Evidence for a Role of Free Fatty Acids in the Regulation of Somatostatin Secretion in Normal and Alloxan Diabetic Dogs
• Turnover and splanchnic metabolism of free fatty acids in hyperthyroid patients.
• Interrelations in the Oxidative Metabolism of Free Fatty Acids, Glucose, and Glycerol in Normal and Hyperlipemic Patients A COMPARTMENTAL MODEL
• Effect of Free Fatty Acids on Myocardial Function and Oxygen Consumption in Intact Dogs
• The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects