Hepatitis B surface antigen and polymerized albumin binding activity in sheep serum.
AUTOR(ES)
Franklin, S G
RESUMO
Sera from sheep and other domestic animals contain a substance that gives a strongly positive test for antibody to hepatitis B virus surface antigen by the accepted radioimmunoassay procedure. We have purified this substance from sheep serum to near homogeneity by ion-exchange, affinity, and molecular exclusion chromatography and have identified it to be an IgM. We present evidence that this sheep IgM is an antibody to polymerized sheep albumin. This antibody may arise due to infection by hepatitis B virus, hepatitis B virus-like viruses, or other pathological agents and may react with hepatitis B virus surface antigen by combining with polymerized albumin bound to the hepatitis B virus receptor for this polymer.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=344719Documentos Relacionados
- Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin
- Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin.
- Sites that bind polymerized albumin on hepatitis B surface antigen particles: detection by radioimmunoassay.
- In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses.
- Relationship of large hepatitis B surface antigen polypeptide to human serum albumin.
