Hepatitis virus and hepatocellular carcinoma in Brazil: a report from the State of Espírito Santo
AUTOR(ES)
Gonçalves, Patrícia Lofêgo, Zago-Gomes, Maria da Penha, Gonçalves, Carlos Sandoval, Pereira, Fausto Edmundo Lima
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2014-10
RESUMO
IntroductionFew studies have examined hepatocellular carcinoma (HCC) in Brazil, and the incidence and risk factors for this type of malignancy vary greatly geographically. In this paper, we report several risk factors associated with HCC diagnosed at the University Hospital in Vitória, ES, Brazil.MethodsWe reviewed 274 cases of HCC (January 1993 to December 2011) in which hepatitis B (HBV) and C (HCV) virus infection and chronic alcoholism were investigated. A diagnosis of hepatocellular carcinoma was confirmed by histology or by the presence of a characteristic pattern on imaging.ResultsHCC with associated liver cirrhosis was noted in 85.4% of cases. The mean ages of men and women were 56.6 years and 57.5 years, respectively. The male-to-female ratio was 5.8:1. Associated risk factors included the following: HBV, 37.6% (alone, 23.4%; associated with chronic alcoholism, 14.2%); HCV, 22.6% (alone, 13.5%; associated with chronic alcoholism, 9.1%), chronic alcoholism, 17.1%, non-alcoholic steatohepatitis, 2.6% and cryptogenic, 19.3%. The male-to-female ratio was higher in cases associated with HBV or chronic alcoholism compared with HCV-associated or cryptogenic cases. In 40 cases without associated cirrhosis, the male-to-female ratio and mean age were lower than those in cirrhosis-associated cases.ConclusionsThese results demonstrate that the main risk factor associated with HCC in the State of Espírito Santo is HBV. Chronic alcoholism is an important etiological factor, alone or in association with HBV or HCV infection.
Documentos Relacionados
- Abortion in association with transplacental Theileria equi infection in a mare from the State of Espírito Santo, southeast Brazil: case report
- The genus Cladonia (Lichenized Ascomycota) from Restinga vegetation of Espírito Santo state, Brazil: Supergroups Cladonia and Cocciferae
- Fauna of Simuliidae (Diptera) from the state of Espírito Santo, Brazil: distribution, new records and list of species
- Epidemiology of hepatitis B virus in the cities of the northern region of Espírito Santo, Brazil
- Hepatitis C virus replication in hepatocellular carcinoma.