Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein.

AUTOR(ES)

Jung, J U

RESUMO

The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now report that STP-C488 is phosphorylated in vivo. The phosphorylated form, which accounted for about 15% of STP-C488 in transformed cells, migrated slightly more slowly through sodium dodecyl sulfate-polyacrylamide gels than unphosphorylated STP-C488. A serine residue near the amino terminus was shown to be the site of phosphorylation. However, phosphorylation was not required for transformation of Rat-1 cells by STP-C488.

Documentos Relacionados

• Identification and characterization of the herpesvirus saimiri oncoprotein STP-C488.
• Association of the viral oncoprotein STP-C488 with cellular ras.
• Herpesvirus Ateles Tio Can Replace Herpesvirus Saimiri StpC and Tip Oncoproteins in Growth Transformation of Monkey and Human T Cells
• Regulation of the herpesvirus saimiri oncogene stpC, similar to that of T-cell activation genes, in growth-transformed human T lymphocytes.
• Substitution of ras for the Herpesvirus Saimiri STP Oncogene in Lymphocyte Transformation