High-Frequency Rugose Exopolysaccharide Production by Vibrio cholerae
AUTOR(ES)
Ali, Afsar
FONTE
American Society for Microbiology
RESUMO
Vibrio cholerae can shift to a “rugose” phenotype, thereby producing copious exopolysaccharide (EPS), which promotes its environmental survival and persistence. We report conditions that promote high-frequency rugose EPS production (HFRP), whereby cells switch at high frequency (up to 80%) to rugose EPS production. HFRP appeared to be more common in clinical strains, as HFRP was found in 6 of 19 clinical strains (32%) (including classical, El Tor, and non-O1 strains) but in only 1 of 16 environmental strains (6%). Differences were found between strains in rugose colony morphology, conditions promoting HFRP, the frequency of rugose-to-smooth (R-S) cell reversion, and biofilm formation. We propose that rugose EPS and HFRP provide an evolutionary and adaptive advantage to specific epidemic V. cholerae strains for increased persistence in the environment.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=129946Documentos Relacionados
- High-frequency spontaneous mutation of classical Vibrio cholerae to a nonmotile phenotype.
- High-frequency heterokaryon formation by Mucor racemosus.
- High-frequency transformation of Rhizobium meliloti.
- High-frequency switching in Candida albicans.
- High-frequency RNA recombination of murine coronaviruses.
