High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain.

AUTOR(ES)

Matus, A

RESUMO

The distributions of tubulin and high molecular weight microtubule-associated proteins (HMWPs) in brain were determined by immunoperoxidase histochemistry with specific antisera. Tubulin was found in microtubules of both neurons and glia and both axons and dendrites. HMWPs were found only in neurons where, in all cases examined, they were associated with dendritic microtubules but not those in axons. Both tubulin and HMWPs were also found in postsynaptic densities. These results indicate that brain microtubules vary in chemical composition. The preferential association of HMWPs with dendritic microtubules suggests that they may play a role in distinguishing between dendritic and axonal export routes from the cell body.

Documentos Relacionados

• Low molecular weight microtubule-associated proteins are light chains of microtubule-associated protein 1 (MAP 1).
• High molecular weight polypeptides (270,000-340,000) from cultured cells are related to hog brain microtubule-associated proteins but copurify with intermediate filaments.
• Microtubule Binding Proteins Are Not Necessarily Microtubule-Associated Proteins.
• Mapmodulin: A possible modulator of the interaction of microtubule-associated proteins with microtubules
• Binding of adenovirus to microtubules. II. Depletion of high-molecular-weight microtubule-associated protein content reduces specificity of in vitro binding.