High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1.
AUTOR(ES)
Kimball, A S
RESUMO
The DNA-binding domain of Epstein-Barr virus nuclear antigen 1 was found by hydroxyl radical footprinting to protect backbone positions on one side of its DNA-binding site. The guanines contacted in the major groove by the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 were identified by methylation protection. No difference was found in the interaction of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1 with tandemly repeated and overlapping binding sites.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362348Documentos Relacionados
- Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites.
- Solubilization of the Epstein-Barr virus-determined nuclear antigen and its characterization as a DNA-binding protein.
- Epstein-Barr virus nuclear antigen forms a complex that binds with high concentration dependence to a single DNA-binding site.
- trans activation of an Epstein-Barr viral transcriptional enhancer by the Epstein-Barr viral nuclear antigen 1.
- Epstein-Barr nuclear antigen 1 mediates a DNA loop within the latent replication origin of Epstein-Barr virus.