Hipótese evolutiva sobre a assimilição de compostos nitrogenados por metazoários: a limitação α-aminoácidos / Evolutionary hypothesis on the nitrogenous compounds uptake by metazoan: the limitation to α-aminoacids

AUTOR(ES)

Erik Montagna

DATA DE PUBLICAÇÃO

2008

RESUMO

Metabolic pathway evolution models are molecular and computational based, and do not take account the physiological and ecological contexts in which organisms are inserted. Thus using the nitrogen metabolism as a platform, an evolutionary hypothesis on the α-amino acids utilization by metazoans was proposed. The objective of the present work is to trace an evolutionary history of the nitrogen usage by metazoans taking account the profile changes on a physiological and ecological basis. In order to trace this evolutionary history, a scrutiny were performed in the specialized literature aiming at data about the molecular and metabolic elements which perform the nitrogen cycle and in which geologic and evolutive context has passed such history. The reorganization of obtained data in a new context allowed original conclusions in the present work as follows: (1) the capability of fixing the atmospheric nitrogen was a positive selection factor in the atmospheric condition transition from reductive to oxidant; (2) nitrogen fixing organisms are far most wide spread than classically admitted; (3) α-amino acids are the biological nitrogen fixation end product in vivo, and are a selective factor for non-fixing organisms; (4) metazoans evolved afterwards in these scenario and their metabolic apparatus is adapted to the nitrogen net utilization obtained in the α-amino acid form.

ASSUNTO(S)

fixação biológica de nitrogênio evolução molecular evolução do metabolismo de nitrogênio ecologia de diazótrofos nitrogenase nitrogenase diazotroph ecology metazoan nitrogen metabolism evolution molecular evolution bioenergetics bioenergética metabolismo de nitrogênio em metazoários biological nitrogen fixation nitrogen metabolism evolution

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