HL-A8: a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy
AUTOR(ES)
Katz, Stephen I.
RESUMO
Histocompatibility antigen HL-A8 was found in 58% of 26 patients with dermatitis herpetiformis (DH) compared to 24% of a normal group. This difference in antigen frequency is significant at the P < 0.003 level. In a previous study, the frequency of this same genetic marker was found to be significantly increased in patients with gluten-sensitive enteropathy (GSE) (88% in patients vs. 22% in controls). The finding of an increased incidence of the HL-A8 antigen in both DH and GSE supports the concept that these diseases are related and provides a genetic basis for the association between the two.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292449Documentos Relacionados
- Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathy
- An in vitro model of gluten-sensitive enteropathy. Effect of gliadin on intestinal epithelial cells of patients with gluten-sensitive enteropathy in organ culture.
- Gluten-sensitive Enteropathy: INFLUENCE OF HISTOCOMPATIBILITY TYPE ON GLUTEN SENSITIVITY IN VITRO
- Extended major histocompatibility complex haplotypes in patients with gluten-sensitive enteropathy.
- Dermatitis Herpetiformis IMMUNOLOGIC CONCOMITANTS OF SMALL INTESTINAL DISEASE AND RELATIONSHIP TO HISTOCOMPATIBILITY ANTIGEN HL-A8