HLA Compatibility Requirements for CD8+-T-Cell-Mediated Suppression of Human Immunodeficiency Virus Replication

AUTOR(ES)

Mackewicz, Carl E.

FONTE

American Society for Microbiology

RESUMO

CD8+ T cells from human immunodeficiency virus (HIV)-infected individuals can suppress HIV replication in cultured CD4+ cells by a noncytotoxic mechanism. Efficient suppression of HIV replication (>90% reduction) does not require HLA class I or class II histocompatibility between the effector CD8+ T cells and the infected target CD4+ T cells. However, maximal control of HIV production occurs when the CD8+ effector cells and CD4+ target cells are syngeneic. In some cases, more than 20-fold fewer syngeneic CD8+ T cells were required to achieve the same degree of HIV inhibition as HLA-mismatched CD8+ T cells. The increased antiviral activity seen in the syngeneic setting did not map exclusively to either the HLA class I or class II locus. These findings suggest that genetic compatibility (potentially, but not necessarily, at the HLA class I and class II loci) regulates CD8+ T-cell noncytotoxic antiviral activity against infected CD4+ T cells.

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