Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen

AUTOR(ES)

Shackelford, Deborah A.

RESUMO

Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.

Documentos Relacionados

• Expression of HLA-DR antigen in human class II mutant B-cell lines by double infection with retrovirus vectors.
• Translation and assembly of HLA-DR antigens in Xenopus oocytes injected with mRNA from a human B-cell line.
• Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.
• HLA-DR expression and soluble HLA-DR levels in septic patients after trauma.
• A comparative analysis of conventional and pretargeted radioimmunotherapy of B-cell lymphomas by targeting CD20, CD22, and HLA-DR singly and in combinations