Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°C
AUTOR(ES)
Breslin, Jamie J.
FONTE
American Society for Microbiology
RESUMO
Truncated human coronavirus HCoV-229E spike glycoproteins containing amino acids 407 to 547 bound to purified, soluble virus receptor, human aminopeptidase N (hAPN). Soluble hAPN neutralized the infectivity of HCoV-229E virions at 37°C, but not 4°C. Binding of hAPN may therefore trigger conformational changes in the viral spike protein at 37°C that facilitate virus entry.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=150646Documentos Relacionados
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