Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.
AUTOR(ES)
Goodwin, R G
RESUMO
A cDNA encoding biologically active human interleukin 7 was isolated by hybridization with the homologous murine clone. Nucleotide sequence analysis indicated that this cDNA was capable of encoding a protein of 177 amino acids with a signal sequence of 25 amino acids and a calculated mass of 17.4 kDa for the mature protein. Recombinant human interleukin 7 stimulated the proliferation of murine pre-B cells and was active on cells harvested from human bone marrow that are enriched for B-lineage progenitor cells. Analysis of RNA by blot hybridization demonstrated the presence of two size classes of interleukin 7 mRNA in human splenic and thymic tissue.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=286452Documentos Relacionados
- Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.
- Replication and Subnuclear Location Dynamics of the Immunoglobulin Heavy-Chain Locus in B-Lineage Cells
- Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome.
- v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
- Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells.
