Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization.
AUTOR(ES)
Nedwin, G E
RESUMO
Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=321958Documentos Relacionados
- Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.
- Structure, expression and chromosomal localization of human p80-coilin gene.
- Human transferrin: cDNA characterization and chromosomal localization.
- Histidine biosynthetic pathway and genes: structure, regulation, and evolution.
- Regulation of human lung fibroblast glycosaminoglycan production by recombinant interferons, tumor necrosis factor, and lymphotoxin.