Human Serum Activities against Hemophilus influenzae, Type b
AUTOR(ES)
Anderson, Porter
RESUMO
Humoral immunity to Hemophilus influenzae, type b was studied in normal human adults by means of assays for serum bactericidal and opsonizing activities against the organism and for passive hemagglutinating activity using erythrocytes sensitized with polyribophosphate, the type-specific capsular antigen. Hemagglutinating activity was detectable in about 60% of the 114 sera tested. Serum bactericidal and opsonizing activities were found in all sera tested; the levels in some sera, however, were quite low. The antibacterial activities were due not only to antibodies directed against the polyribophosphate capsule but also to antibodies that appear to be directed against somatic antigens. Type b strains differed in their susceptibility to the antisomatic antibodies of particular sera but were uniformly sensitive to anticapsular antibody.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=332925Documentos Relacionados
- Hemophilus influenzae, Type b, Antibody Frequencies Determined with Bactericidal and Radioimmunoassay Tests
- Immunization of Humans with Polyribophosphate, the Capsular Antigen of Hemophilus influenzae, Type b
- Circulating polyribophosphate in Hemophilus influenzae, type b meningitis. Correlation with clinical course and antibody response.
- Pathophysiology of hemolysis in infections with Hemophilus influenzae type b.
- QUANTITATIVE DETERMINATION, IN TYPE-SPECIFIC ANTISERA TO HEMOPHILUS INFLUENZAE, OF THE ANTIBODY THAT CROSS-REACTS WITH ENCAPSULATED PNEUMOCOCCI1