Hyphae and Yeasts of Candida albicans Differentially Regulate Interleukin-12 Production by Human Blood Monocytes: Inhibitory Role of C. albicans Germination
AUTOR(ES)
Liu, Liming
FONTE
American Society for Microbiology
RESUMO
The role of Candida albicans yeast-to-hypha transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=98552Documentos Relacionados
- Candida albicans and Candida krusei Differentially Induce Human Blood Mononuclear Cell Interleukin-12 and Gamma Interferon Production
- Defective Induction of Interleukin-12 in Human Monocytes by Germ-Tube Forms of Candida albicans
- Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.
- Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy.
- Inhibition of Monocytic Interleukin-12 Production by Candida albicans via Selective Activation of ERK Mitogen-Activated Protein Kinase
