Identificação, classificação e anotação de enzimas análogas em tripanossomatídeos / Identificação, classificação e anotação de enzimas análogas em tripanossomatídeos / Identification, classification and notation of analogous enzyme in Trypanosoma / Identification, classification and notation of analogous enzyme in Trypanosoma

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Enzymes are proteins capable of catalyzing chemical reactions. Analogous enzymes are alternative forms of a determined enzymatic function, and are interesting subjects for the development of studies about the evolution of genes and metabolic pathways. Analogous enzymes also represent potential drug targets, since the criteria for searching and selecting these targets are normally based in the specificity of enzymatic functions and not in the evolutionary origin of the different forms of a determined enzyme. In this work, we implemented a tool (AnEnp) capable of clustering protein sequences and visualizing the results; it also carries out similarity searches via BLAST and/or HMMER and reconstructs metabolic maps. With this tool it was possible to analyze data about the presence/absence of enzymatic functions in the genomes of Trypanosoma cruzi, Trypanosoma brucei and Leishmania major. These data were compiled, stored and analyzed. In addition, the variability of the metabolic pathways was studied, taking into account the existence of analogy events between trypanosomatids and the human being. A list of possible targets for development of new drugs was produced.

ASSUNTO(S)

analogous enzyme trypanosoma trypanosoma biologia molecular enzimas analógicas

ACESSO AO ARTIGO

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