Identification and characterization of the hamster polyomavirus middle T antigen.
AUTOR(ES)
Courtneidge, S A
RESUMO
Hamster polyomavirus (HaPV) is associated with lymphoid and hair follicle tumors in Syrian hamsters. The early region of HaPV has the potential to encode three polypeptides (which are related to the mouse polyomavirus early proteins) and can transform fibroblasts in vitro. We identified the HaPV middle T antigen (HamT) as a 45-kDa protein. Like its murine counterpart, HamT was associated with serine/threonine phosphatase, phosphatidylinositol-3 kinase, and protein tyrosine kinase activities. However, whereas mouse middle T antigen associates predominantly with pp60c-src and pp62c-yes, HamT was associated with a different tyrosine kinase, p59fyn. The ability of HaPV to cause lymphoid tumors may therefore reside in its ability to associate with p59fyn, a potentially important tyrosine kinase in lymphocytes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=240988Documentos Relacionados
- Multimerization of polyomavirus middle-T antigen.
- Functional interaction between the SH2 domain of Fyn and tyrosine 324 of hamster polyomavirus middle-T antigen.
- Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen.
- In vitro mutagenesis of the putative membrane-binding domain of polyomavirus middle-T antigen.
- Functional asymmetry of the regions juxtaposed to the membrane-binding sequence of polyomavirus middle T antigen.
