Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

AUTOR(ES)

Madison, Bereneice M.

FONTE

American Society for Microbiology

RESUMO

We have identified a potential quality control strain of Mycobacterium tuberculosis to monitor isoniazid susceptibility testing. This strain (strain A) has a stable phenotypic low-level resistance to isoniazid, has a mutation of C (−15) → T in the inhA promoter region, and gave consistent susceptibility test results in 141 laboratories.

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