Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls.
AUTOR(ES)
Sánchez, F O
RESUMO
The aim of the present study was to determine the profile of immune responsiveness that differentiates patients with tuberculosis (TB) from healthy tuberculin-positive controls. Forty-five patients with pulmonary TB and 16 healthy tuberculin-positive controls, all human immunodeficiency virus negative, were studied. Patients had decreased reactivity to tuberculin, diminished proliferative response to purified protein derivative (PPD), lower concentrations of interleukin-2 (IL-2) and gamma interferon in PPD-stimulated cultures, no increase in the percentage of gamma/delta cells in PPD-stimulated cultures, and higher immunoglobulin G antimycobacterial antibodies compared with control subjects. Furthermore, controls exhibited decreased production of IL-4 by PPD-stimulated cells. Multivariate discriminant and factor analyses demonstrated divergent patterns of immune reactivity against mycobacterial antigens. The association of IL-4 and immunoglobulin G antibody levels in patients, in contrast to the high reactivity to tuberculin, increased proliferation to PPD, and higher levels of IL-2 and gamma interferon observed in healthy controls suggested that most TB patients exhibit a TH2 pattern of immune responsiveness while tuberculin-positive healthy individuals have a TH1 pattern.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=303319Documentos Relacionados
- Hafnia alvei in stool specimens from patients with diarrhea and healthy controls.
- Antibodies to Mycoplasma hominis in patients with genital infections and in healthy controls.
- Comparison of sleep in osteoarthritic patients and age and sex matched healthy controls.
- Computed tomography and psychometric test performances in patients with solvent induced chronic toxic encephalopathy and healthy controls.
- Corneal sensitivity in patients with leprosy and in controls.