Immunization against the polyoma virus-induced tumor-specific transplantation antigen by early region mutants of the virus.
AUTOR(ES)
Dalianis, T
RESUMO
To investigate the relation between the polyoma tumor-specific transplantation antigen and the virus-coded proteins, mice were immunized by inoculation of a variety of viable polyoma virus mutants and then challenged with polyoma virus-induced tumors. Two classes of early region mutants were used. One class produces a normal small T-antigen and truncated middle and large T-antigens. The second class (hr-t mutants) forms a normal large T-antigen together with N-terminal fragments of small and middle T-antigens. All mutants, transforming as well as nontransforming, induced protection against polyoma virus tumors. However, there were quantitive differences between the mutants. The finding that an hr-t mutant could induce tumor rejection suggests that full-length middle and small T-antigens are not necessary for the induction of this response. Since intact middle T-antigen is the only virus-coded protein known to associate with the plasma membrane, the possibility must be considered that the polyoma virus tumor-specific transplantation antigen consists of cellular components.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=256187Documentos Relacionados
- Relationship between T-antigen and tumor-specific transplantation antigen in simian virus 40-transformed cells.
- Myeloma Proteins as Tumor-Specific Transplantation Antigens
- Induction of tumor-specific cell-mediated immunity by a noninfectious type-C virus.
- A mouse tumor-specific transplantation antigen is a heat shock-related protein.
- Expression of tumor-specific transplantation antigen in cell lines transformed by wild-type of tsA mutant simian virus 40.